Robust and Efficient Assessment of Potency (REAP) as a quantitative tool for dose-response curve estimation

The median-effect equation has been widely used to describe the dose-response relationship and identify compounds that activate or inhibit specific disease targets in contemporary drug discovery. However, the experimental data often contain extreme responses, which may significantly impair the estim...

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Detalles Bibliográficos
Autores principales: Zhou, Shouhao, Liu, Xinyi, Fang, Xinying, Chinchilli, Vernon M, Wang, Michael, Wang, Hong-Gang, Dokholyan, Nikolay V, Shen, Chan, Lee, J Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348845/
https://www.ncbi.nlm.nih.gov/pubmed/35921131
http://dx.doi.org/10.7554/eLife.78634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348845/
https://www.ncbi.nlm.nih.gov/pubmed/35921131
http://dx.doi.org/10.7554/eLife.78634

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