Cargando…
Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels
Otopetrin (OTOP) channels are proton-selective ion channels conserved among vertebrates and invertebrates, with no structural similarity to other ion channels. There are three vertebrate OTOP channels (OTOP1, OTOP2, and OTOP3), of which one (OTOP1) functions as a sour taste receptor. Whether extrace...
Autores principales: | Teng, Bochuan, Kaplan, Joshua P, Liang, Ziyu, Krieger, Zachary, Tu, Yu-Hsiang, Burendei, Batuujin, Ward, Andrew B, Liman, Emily R |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348849/ https://www.ncbi.nlm.nih.gov/pubmed/35920807 http://dx.doi.org/10.7554/eLife.77946 |
Ejemplares similares
-
Structures of the Otopetrin Proton Channels Otop1 and Otop3
por: Saotome, Kei, et al.
Publicado: (2019) -
Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members
por: Hughes, Inna, et al.
Publicado: (2008) -
Requirement for an Otopetrin-like protein for acid taste in Drosophila
por: Ganguly, Anindya, et al.
Publicado: (2021) -
Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus
por: Teng, Bochuan, et al.
Publicado: (2023) -
Loss of Otopetrin 1 affects thermoregulation during fasting in mice
por: Tu, Yu-Hsiang, et al.
Publicado: (2023)