Prediction of Maternal and Fetal Doravirine Exposure by Integrating Physiologically Based Pharmacokinetic Modeling and Human Placenta Perfusion Experiments

BACKGROUND AND OBJECTIVE: Doravirine is currently not recommended for pregnant women living with human immunodeficiency virus because efficacy and safety data are lacking. This study aimed to predict maternal and fetal doravirine exposure by integrating human placenta perfusion experiments with preg...

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Detalles Bibliográficos
Autores principales: Bukkems, V. E., van Hove, H., Roelofsen, D., Freriksen, J. J. M., van Ewijk-Beneken Kolmer, E. W. J., Burger, D. M., van Drongelen, J., Svensson, E. M., Greupink, R., Colbers, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349081/
https://www.ncbi.nlm.nih.gov/pubmed/35579825
http://dx.doi.org/10.1007/s40262-022-01127-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349081/
https://www.ncbi.nlm.nih.gov/pubmed/35579825
http://dx.doi.org/10.1007/s40262-022-01127-0

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