Cargando…

Peptidic defective interfering gene nanoparticles against Omicron, Delta SARS-CoV-2 variants and influenza A virus in vivo

Defective interfering genes (DIGs) are short viral genomes and interfere with wild-type viral replication. Here, we demonstrate that the new designed SARS-CoV-2 DIG (CD3600) can significantly inhibit the replication of SARS-CoV-2 including Alpha, Delta, Kappa and Omicron variants in human HK-2 cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Hanjun, Zhang, Chuyuan, Lam, Hoiyan, Meng, Xinjie, Peng, Zheng, Yeung, Man Lung, Chan, Jasper Fuk-Woo, Kai-Wang To, Kelvin, Yuen, Kwok-Yung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349215/ https://www.ncbi.nlm.nih.gov/pubmed/35922403 http://dx.doi.org/10.1038/s41392-022-01138-0

Ejemplares similares

Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants
por: Zhao, Hanjun, et al.
Publicado: (2022)

A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters
por: Zhao, Hanjun, et al.
Publicado: (2022)

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2
por: Zhao, Hanjun, et al.
Publicado: (2020)

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza
por: Zhao, Hanjun, et al.
Publicado: (2018)

SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection
por: Lui, Wing-Yu, et al.
Publicado: (2019)

Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2
por: Zhao, Hanjun, et al.
Publicado: (2021)

Host genes and influenza pathogenesis in humans: an emerging paradigm
por: To, Kelvin Kai-Wang, et al.
Publicado: (2015)

SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells
por: Zhao, Hanjun, et al.
Publicado: (2022)

Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size
por: Fong, Carol Ho-Yan, et al.
Publicado: (2022)

Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2
por: Zhang, Chuyuan, et al.
Publicado: (2022)

Cross-species transmission and emergence of novel viruses from birds
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2015)

The Therapeutic Effect of Pamidronate on Lethal Avian Influenza A H7N9 Virus Infected Humanized Mice
por: Zheng, Jian, et al.
Publicado: (2015)

Defective interfering virus protects elderly mice from influenza
por: Scott, Paul D, et al.
Publicado: (2011)

Influenza virus DI particles: Defective interfering or delightfully interesting?
por: Alnaji, Fadi G., et al.
Publicado: (2020)

Interspecies transmission and emergence of novel viruses: lessons from bats and birds
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2013)

The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities
por: To, Kelvin KW, et al.
Publicado: (2013)

Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis
por: Sridhar, Siddharth, et al.
Publicado: (2014)

Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant
por: Xia, Shuai, et al.
Publicado: (2022)

Identification and characterization of GLDC as host susceptibility gene to severe influenza
por: Zhou, Jie, et al.
Publicado: (2018)

Differentiated human airway organoids to assess infectivity of emerging influenza virus
por: Zhou, Jie, et al.
Publicado: (2018)

Pathogenicity of SARS‐CoV‐2 Omicron
por: Chu, Hin, et al.
Publicado: (2022)

A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant
por: Chiu, Man Chun, et al.
Publicado: (2022)

A Palmitic Acid-Conjugated, Peptide-Based pan-CoV Fusion Inhibitor Potently Inhibits Infection of SARS-CoV-2 Omicron and Other Variants of Concern
por: Lan, Qiaoshuai, et al.
Publicado: (2022)

ACE2‐enriched extracellular vesicles enhance infectivity of live SARS‐CoV‐2 virus
por: Tey, Sze Keong, et al.
Publicado: (2022)

Evidence that two instead of one defective interfering RNA in influenza A virus-derived defective interfering particles (DIPs) does not enhance antiviral activity
por: Bdeir, Najat, et al.
Publicado: (2021)

Small Interfering RNA Targeting M2 Gene Induces Effective and Long Term Inhibition of Influenza A Virus Replication
por: Sui, Hong-Yan, et al.
Publicado: (2009)

Intranasal infection by SARS-CoV-2 Omicron variants can induce inflammatory brain damage in newly weaned hamsters
por: Li, Can, et al.
Publicado: (2023)

The frequency of defective genomes in Omicron differs from that of the Alpha, Beta and Delta variants
por: Campos, Carolina, et al.
Publicado: (2022)

Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis
por: Zhou, Jie, et al.
Publicado: (2015)

Absence of nosocomial influenza and respiratory syncytial virus infection in the coronavirus disease 2019 (COVID-19) era: Implication of universal masking in hospitals
por: Wong, Shuk-Ching, et al.
Publicado: (2020)

Pathogenicity of SARS-CoV-2 Omicron BA.1.1 in hamsters
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2022)

(In)validating experimentally derived knowledge about influenza A defective interfering particles
por: Liao, Laura E., et al.
Publicado: (2016)

Cell culture-based production of defective interfering particles for influenza antiviral therapy
por: Wasik, Milena A., et al.
Publicado: (2017)

Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA
por: Meng, Bo, et al.
Publicado: (2017)

Accurate Diagnosis of COVID-19 by a Novel Immunogenic Secreted SARS-CoV-2 orf8 Protein
por: Wang, Xiaohui, et al.
Publicado: (2020)

Response to Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity
por: Yeung, Man Lung, et al.
Publicado: (2022)

A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants
por: Lam, Joy-Yan, et al.
Publicado: (2022)

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2020)

SPINK6 inhibits human airway serine proteases and restricts influenza virus activation
por: Wang, Dong, et al.
Publicado: (2021)

A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge
por: Zhou, Biao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dr30khi0bfvm1tiafb38v9ptn8