β subunits of GABA(A) receptors form proton-gated chloride channels: Insights into the molecular basis

Gamma-aminobutyric acid type A receptors (GABA(A)Rs) are ligand gated channels mediating inhibition in the central nervous system. Here, we identify a so far undescribed function of β-subunit homomers as proton-gated anion channels. Mutation of a single H267A in β3 subunits completely abolishes chan...

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Detalles Bibliográficos
Autores principales: Garifulina, Aleksandra, Friesacher, Theres, Stadler, Marco, Zangerl-Plessl, Eva-Maria, Ernst, Margot, Stary-Weinzinger, Anna, Willam, Anita, Hering, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349252/
https://www.ncbi.nlm.nih.gov/pubmed/35922471
http://dx.doi.org/10.1038/s42003-022-03720-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349252/
https://www.ncbi.nlm.nih.gov/pubmed/35922471
http://dx.doi.org/10.1038/s42003-022-03720-2

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