AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis

Macrocyclization is an important process that affords morphed scaffold in biosynthesis of bioactive natural products. Nature has adapted diverse biosynthetic strategies to form macrocycles. In this work, we report the identification and characterization of a small enzyme AvmM that can catalyze the c...

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Detalles Bibliográficos
Autores principales: Zhu, Hong Jie, Zhang, Bo, Wei, Wanqing, Liu, Shuang He, Xiang, Lang, Zhu, Jiapeng, Jiao, Rui Hua, Igarashi, Yasuhiro, Bashiri, Ghader, Liang, Yong, Tan, Ren Xiang, Ge, Hui Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349299/
https://www.ncbi.nlm.nih.gov/pubmed/35922406
http://dx.doi.org/10.1038/s41467-022-32088-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349299/
https://www.ncbi.nlm.nih.gov/pubmed/35922406
http://dx.doi.org/10.1038/s41467-022-32088-4

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