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AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis
Macrocyclization is an important process that affords morphed scaffold in biosynthesis of bioactive natural products. Nature has adapted diverse biosynthetic strategies to form macrocycles. In this work, we report the identification and characterization of a small enzyme AvmM that can catalyze the c...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349299/ https://www.ncbi.nlm.nih.gov/pubmed/35922406 http://dx.doi.org/10.1038/s41467-022-32088-4 |