PERK/EIF2AK3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells

Retinal pigment epithelium (RPE) performs essential functions for ensuring retinal homeostasis and is a key site for pathogenic changes leading to age-related macular degeneration (AMD). Compromised proteostasis in RPE results in ER stress and ER stress-dependent antioxidant, apoptosis and autophagi...

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Detalles Bibliográficos
Autores principales: Saptarshi, Neil, Porter, Louise F., Paraoan, Luminita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349321/
https://www.ncbi.nlm.nih.gov/pubmed/35922637
http://dx.doi.org/10.1038/s41598-022-16909-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349321/
https://www.ncbi.nlm.nih.gov/pubmed/35922637
http://dx.doi.org/10.1038/s41598-022-16909-6

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