Cargando…

Targeting SARS-CoV-2 endoribonuclease: a structure-based virtual screening supported by in vitro analysis

Researchers are focused on discovering compounds that can interfere with the COVID-19 life cycle. One of the important non-structural proteins is endoribonuclease since it is responsible for processing viral RNA to evade detection of the host defense system. This work investigates a hierarchical str...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ibrahim, Ibrahim M., Elfiky, Abdo A., Fathy, Mohamed M., Mahmoud, Sara H., ElHefnawi, Mahmoud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349323/ https://www.ncbi.nlm.nih.gov/pubmed/35922447 http://dx.doi.org/10.1038/s41598-022-17573-6

Ejemplares similares

Multiple virtual screening approaches for finding new Hepatitis c virus RNA-dependent RNA polymerase inhibitors: Structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors
por: ElHefnawi, Mahmoud, et al.
Publicado: (2012)

Targeting SARS-CoV-2 nonstructural protein 15 endoribonuclease: an in silico perspective
por: Mahmud, Shafi, et al.
Publicado: (2021)

MysiRNA-Designer: A Workflow for Efficient siRNA Design
por: Mysara, Mohamed, et al.
Publicado: (2011)

Identifying potential novel insights for COVID-19 pathogenesis and therapeutics using an integrated bioinformatics analysis of host transcriptome
por: El-aarag, Salem A., et al.
Publicado: (2022)

Computational Identification of Tissue-Specific Splicing Regulatory Elements in Human Genes from RNA-Seq Data
por: Badr, Eman, et al.
Publicado: (2016)

Ensemble-based classification approach for micro-RNA mining applied on diverse metagenomic sequences
por: ElGokhy, Sherin M, et al.
Publicado: (2014)

Prediction of prognostic biomarkers for Interferon-based therapy to Hepatitis C Virus patients: a metaanalysis of the NS5A protein in subtypes 1a, 1b, and 3a
por: ElHefnawi, Mahmoud M, et al.
Publicado: (2010)

Host-cell recognition through GRP78 is enhanced in the new UK variant of SARS-CoV-2, in silico
por: Elfiky, Abdo A, et al.
Publicado: (2021)

Host-cell recognition of SARS-CoV-2 spike receptor binding domain from different variants
por: Elfiky, Abdo A, et al.
Publicado: (2022)

Host-cell recognition through Cs-GRP78 is enhanced in the new Omicron variant of SARS-CoV-2, in silico structural point of view
por: Elfiky, Abdo A, et al.
Publicado: (2022)

An Integrative Meta-analysis of MicroRNAs in Hepatocellular Carcinoma
por: ElHefnawi, Mahmoud, et al.
Publicado: (2013)

Telaprevir is a potential drug for repurposing against SARS-CoV-2: computational and in vitro studies
por: Mahmoud, Amal, et al.
Publicado: (2021)

Structure-based virtual screening suggests inhibitors of 3-Chymotrypsin-Like Protease of SARS-CoV-2 from Vernonia amygdalina and Occinum gratissimum
por: Gyebi, Gideon A., et al.
Publicado: (2021)

Recognition through GRP78 is enhanced in the UK, South African, and Brazilian variants of SARS-CoV-2; An in silico perspective
por: Ibrahim, Ibrahim M., et al.
Publicado: (2021)

SARS-CoV-2 Delta Variant is Recognized Through GRP78 Host-Cell Surface Receptor, In Silico Perspective
por: Elfiky, Abdo A., et al.
Publicado: (2022)

Co-regulatory Network of Oncosuppressor miRNAs and Transcription Factors for Pathology of Human Hepatic Cancer Stem Cells (HCSC)
por: Mohamed, Rania Hassan, et al.
Publicado: (2019)

Interference of Chaga mushroom terpenoids with the attachment of SARS-CoV-2; in silico perspective
por: Elshemey, Wael M., et al.
Publicado: (2022)

Molecular dynamics simulations and MM-GBSA reveal novel guanosine derivatives against SARS-CoV-2 RNA dependent RNA polymerase
por: Elfiky, Abdo A., et al.
Publicado: (2022)

Novel adenosine derivatives against SARS-CoV-2 RNA-dependent RNA polymerase: an in silico perspective
por: Sonousi, Amr, et al.
Publicado: (2021)

Accurate Prediction of Advanced Liver Fibrosis Using the Decision Tree Learning Algorithm in Chronic Hepatitis C Egyptian Patients
por: Hashem, Somaya, et al.
Publicado: (2016)

Derivation of “Egyptian varices prediction (EVP) index”: A novel noninvasive index for diagnosing esophageal varices in HCV Patients
por: Abd-Elsalam, Shimaa M., et al.
Publicado: (2021)

Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease
por: Godoy, Andre Schutzer, et al.
Publicado: (2023)

Identification of novel conserved functional motifs across most Influenza A viral strains
por: ElHefnawi, Mahmoud, et al.
Publicado: (2011)

Atovaquone and Pibrentasvir Inhibit the SARS-CoV-2 Endoribonuclease and Restrict Infection In Vitro but Not In Vivo
por: von Beck, Troy, et al.
Publicado: (2023)

In Silico and In Vivo Evaluation of SARS-CoV-2 Predicted Epitopes-Based Candidate Vaccine
por: Shehata, Mahmoud M., et al.
Publicado: (2021)

In silico identification of potential key regulatory factors in smoking-induced lung cancer
por: El-aarag, Salem A., et al.
Publicado: (2017)

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15
por: Pillon, Monica C., et al.
Publicado: (2020)

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease
por: Canal, Berta, et al.
Publicado: (2021)

Dual targeting of RdRps of SARS-CoV-2 and the mucormycosis-causing fungus: an in silico perspective
por: Elfiky, Abdo A
Publicado: (2022)

RNA Recognition and Cleavage by the SARS Coronavirus Endoribonuclease
por: Bhardwaj, Kanchan, et al.
Publicado: (2006)

In silico identification of novel SARS-COV-2 2′-O-methyltransferase (nsp16) inhibitors: structure-based virtual screening, molecular dynamics simulation and MM-PBSA approaches
por: El Hassab, Mahmoud A., et al.
Publicado: (2021)

Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants
por: Wilson, Isha M., et al.
Publicado: (2022)

Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants
por: Wilson, Isha M., et al.
Publicado: (2022)

Immunomodulatory and Antioxidative potentials of adipose-derived Mesenchymal stem cells isolated from breast versus abdominal tissue: a comparative study
por: Abu-Shahba, Nourhan, et al.
Publicado: (2020)

Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (M(pro)) inhibitors to unveil a hope against COVID-19
por: Adem, Şevki, et al.
Publicado: (2022)

SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) Recognition may be Related to the Immersed Human Coronaviruses
por: Elfiky, Abdo A.
Publicado: (2020)

Expression profiling and analysis of some miRNAs in subcutaneous white adipose tissue during development of obesity
por: Youssef, Elham M., et al.
Publicado: (2020)

Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study
por: Elfiky, Abdo A.
Publicado: (2020)

Genetic variability of the core protein in hepatitis C virus genotype 4 in Saudi Arabian patients and its implication on pegylated interferon and ribavirin therapy
por: Alhamlan, Fatimah S, et al.
Publicado: (2014)

Alkaloids and flavonoids from African phytochemicals as potential inhibitors of SARS-Cov-2 RNA-dependent RNA polymerase: an in silico perspective
por: Ogunyemi, Oludare M, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ftvu915ofgecae2s04f5jjln26