Efficacy of leupeptin in treating ischemia in a rat hind limb model

Prolonged tourniquet use can lead to tissue ischemia and can cause progressive muscle and nerve injuries. Such injuries are accompanied by calpain activation and subsequent Wallerian‐like degeneration. Several known inhibitors, including leupeptin, are known to impede the activity of calpain and ass...

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Detalles Bibliográficos
Autores principales: Gurevich, Mikhail, Iocolano, Kari, Martin, Irene Nozal, Singh, Gurtej, Khan, Sami U., Bui, Duc T., Dagum, Alexander B., Komatsu, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350425/
https://www.ncbi.nlm.nih.gov/pubmed/35924300
http://dx.doi.org/10.14814/phy2.15411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350425/
https://www.ncbi.nlm.nih.gov/pubmed/35924300
http://dx.doi.org/10.14814/phy2.15411

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