Therapeutic drug monitoring of phenytoin and valproic acid in critically ill patients at Windhoek Central Hospital, Namibia

BACKGROUND: Phenytoin and valproic acid, anticonvulsants, have a low therapeutic index and are highly plasma protein bound, mainly to albumin. Hypoalbuminaemia is common in critically ill patients and increases the unbound drug concentration. Thus, monitoring unbound rather than total plasma drug co...

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Detalles Bibliográficos
Autores principales: Singu, Bonifasius S., Morrison, Helen, Irengeya, Lydia, Verbeeck, Roger K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350491/
https://www.ncbi.nlm.nih.gov/pubmed/35937763
http://dx.doi.org/10.4102/ajlm.v11i1.1628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350491/
https://www.ncbi.nlm.nih.gov/pubmed/35937763
http://dx.doi.org/10.4102/ajlm.v11i1.1628

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