All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading

Antibody–drug conjugates (ADCs) are valuable therapeutic entities which leverage the specificity of antibodies to selectively deliver cytotoxins to antigen-expressing targets such as cancer cells. However, current methods for their construction still suffer from a number of shortcomings. For instanc...

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Detalles Bibliográficos
Autores principales: Dannheim, Friederike M., Walsh, Stephen J., Orozco, Carolina T., Hansen, Anders Højgaard, Bargh, Jonathan D., Jackson, Sophie E., Bond, Nicholas J., Parker, Jeremy S., Carroll, Jason S., Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350601/
https://www.ncbi.nlm.nih.gov/pubmed/35975158
http://dx.doi.org/10.1039/d2sc02198f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350601/
https://www.ncbi.nlm.nih.gov/pubmed/35975158
http://dx.doi.org/10.1039/d2sc02198f

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