Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response

Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressing role via its interaction with RNF20 (ring finger...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Liu-Ya, Thomas, Adam, Zhou, Ming, Zhang, Ying E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350827/
https://www.ncbi.nlm.nih.gov/pubmed/33097595
http://dx.doi.org/10.1074/jbc.RA120.014179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350827/
https://www.ncbi.nlm.nih.gov/pubmed/33097595
http://dx.doi.org/10.1074/jbc.RA120.014179

Ejemplares similares