Cargando…

Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response

Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressing role via its interaction with RNF20 (ring finger...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Liu-Ya, Thomas, Adam, Zhou, Ming, Zhang, Ying E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350827/ https://www.ncbi.nlm.nih.gov/pubmed/33097595 http://dx.doi.org/10.1074/jbc.RA120.014179

Ejemplares similares

Negative Role of RIG-I Serine 8 Phosphorylation in the Regulation of Interferon-β Production
por: Nistal-Villán, Estanislao, et al.
Publicado: (2010)

Mechanism of Oxidative DNA Damage in Diabetes : Tuberin Inactivation and Downregulation of DNA Repair Enzyme 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine-DNA Glycosylase
por: Simone, Simona, et al.
Publicado: (2008)

Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)
por: Keshwani, Malik M., et al.
Publicado: (2011)

MYPT1 Protein Isoforms Are Differentially Phosphorylated by Protein Kinase G
por: Yuen, Samantha, et al.
Publicado: (2011)

The Nuclear Localization of γ-Tubulin Is Regulated by SadB-mediated Phosphorylation
por: Eklund, Greta, et al.
Publicado: (2014)

4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass
por: Blandino-Rosano, Manuel, et al.
Publicado: (2016)

Differential G-protein-coupled Receptor Phosphorylation Provides Evidence for a Signaling Bar Code
por: Butcher, Adrian J., et al.
Publicado: (2011)

Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes
por: Mashili, Fredirick, et al.
Publicado: (2013)

Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes
por: Roberts, David J., et al.
Publicado: (2013)

Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain Tissue
por: Schrötter, Sandra, et al.
Publicado: (2016)

β(2)-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function
por: Kim, Donghwa, et al.
Publicado: (2016)

A New Pathway of CD5 Glycoprotein-mediated T Cell Inhibition Dependent on Inhibitory Phosphorylation of Fyn Kinase
por: Bamberger, Martina, et al.
Publicado: (2011)

Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders
por: Li, Min, et al.
Publicado: (2015)

Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis
por: Kuo, Taiyi, et al.
Publicado: (2017)

Signaling to Extracellular Signal-regulated Kinase from ErbB1 Kinase and Protein Kinase C: FEEDBACK, HETEROGENEITY, AND GATING
por: Perrett, Rebecca M, et al.
Publicado: (2013)

Syk-dependent Phosphorylation of CLEC-2: A NOVEL MECHANISM OF HEM-IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF SIGNALING
por: Séverin, Sonia, et al.
Publicado: (2011)

Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1ϵ and Frizzled5
por: Bernatík, Ondřej, et al.
Publicado: (2014)

Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity
por: Burmeister, Brian T., et al.
Publicado: (2015)

Concomitant Action of Structural Elements and Receptor Phosphorylation Determines Arrestin-3 Interaction with the Free Fatty Acid Receptor FFA4
por: Butcher, Adrian J., et al.
Publicado: (2014)

p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration
por: Samson, Shiela C., et al.
Publicado: (2019)

Information Transfer in Gonadotropin-releasing Hormone (GnRH) Signaling: EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK)-MEDIATED FEEDBACK LOOPS CONTROL HORMONE SENSING
por: Garner, Kathryn L., et al.
Publicado: (2016)

Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)(536) Phosphorylation
por: Zhao, Yanhua, et al.
Publicado: (2011)

In Vivo Phosphorylation of Ser(21) and Ser(83) during Nutrient-induced Activation of the Yeast Protein Kinase A (PKA) Target Trehalase
por: Schepers, Wim, et al.
Publicado: (2012)

Target of rapamycin complex 2–dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae
por: Bourgoint, Clélia, et al.
Publicado: (2018)

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I
por: Sevrieva, Ivanka R., et al.
Publicado: (2020)

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets
por: Moore, Samantha F., et al.
Publicado: (2011)

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells
por: Haushalter, Kristofer J., et al.
Publicado: (2018)

Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2: INSIGHTS FROM INTACT CELL PHOSPHORYLATION AND RECRUITMENT ASSAYS
por: Beautrait, Alexandre, et al.
Publicado: (2014)

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines
por: Thaker, Youg R., et al.
Publicado: (2017)

Serine 34 Phosphorylation of Rho Guanine Dissociation Inhibitor (RhoGDIα) Links Signaling from Conventional Protein Kinase C to RhoGTPase in Cell Adhesion
por: Dovas, Athanassios, et al.
Publicado: (2010)

Phosphorylation of Rat Melanopsin at Ser-381 and Ser-398 by Light/Dark and Its Importance for Intrinsically Photosensitive Ganglion Cells (ipRGCs) Cellular Ca(2+) Signaling
por: Fahrenkrug, Jan, et al.
Publicado: (2014)

Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways
por: Dickinson, Robin J., et al.
Publicado: (2011)

Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity
por: Sajan, Mini P., et al.
Publicado: (2014)

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1
por: Morén, Anita, et al.
Publicado: (2011)

p38 Mitogen-Activated Protein Kinase-Dependent Transactivation of ErbB Receptor Family: A Novel Common Mechanism for Stress-Induced IRS-1 Serine Phosphorylation and Insulin Resistance
por: Hemi, Rina, et al.
Publicado: (2011)

Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor: Implications for Diabetic Nephropathy
por: Fragiadaki, Maria, et al.
Publicado: (2012)

Protein Kinase Cθ Negatively Regulates Store-independent Ca(2+) Entry and Phosphatidylserine Exposure Downstream of Glycoprotein VI in Platelets
por: Harper, Matthew T., et al.
Publicado: (2010)

Canonical Transient Receptor Potential (TRPC) 1 Acts as a Negative Regulator for Vanilloid TRPV6-mediated Ca(2+) Influx
por: Schindl, Rainer, et al.
Publicado: (2012)

Signal Integration and Coincidence Detection in the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Cascade: CONCOMITANT ACTIVATION OF RECEPTOR TYROSINE KINASES AND OF LRP-1 LEADS TO SUSTAINED ERK PHOSPHORYLATION VIA DOWN-REGULATION OF DUAL SPECIFICITY PHOSPHATASES (DUSP1 AND -6)
por: Geetha, Nishamol, et al.
Publicado: (2011)

Caveolin-1 Alters the Pattern of Cytoplasmic Ca(2+) Oscillations and Ca(2+)-dependent Gene Expression by Enhancing Leukotriene Receptor Desensitization
por: Yeh, Yi-Chun, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qnn5ft1jm3uvffsndnvnimn4r3