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Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response

Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressing role via its interaction with RNF20 (ring finger...

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Detalles Bibliográficos
Autores principales:	Tang, Liu-Ya, Thomas, Adam, Zhou, Ming, Zhang, Ying E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350827/ https://www.ncbi.nlm.nih.gov/pubmed/33097595 http://dx.doi.org/10.1074/jbc.RA120.014179

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