A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

The transcriptional coactivator YAP1 is the major oncogenic component of the Hippo signaling pathway and contributes to the genesis and progression of various tumors, including non–small cell lung cancer (NSCLC). YAP1 levels are regulated by the canonical Hippo kinases, MST1/2 and LATS1/2, which mod...

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Detalles Bibliográficos
Autores principales: Bora-Singhal, Namrata, Saha, Biswarup, Mohankumar, Durairaj, Padmanabhan, Jaya, Coppola, Domenico, Chellappan, Srikumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351435/
https://www.ncbi.nlm.nih.gov/pubmed/35937460
http://dx.doi.org/10.1158/2767-9764.CRC-21-0084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351435/
https://www.ncbi.nlm.nih.gov/pubmed/35937460
http://dx.doi.org/10.1158/2767-9764.CRC-21-0084

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