Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo

Heparan sulfate proteoglycans (HSPGs) mediate essential interactions throughout the extracellular matrix (ECM), providing signals that regulate cellular growth and development. Altered HSPG composition during tumorigenesis strongly aids cancer progression. Heparanase (HPSE) is the principal enzyme r...

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Detalles Bibliográficos
Autores principales: de Boer, Casper, Armstrong, Zachary, Lit, Vincent A. J., Barash, Uri, Ruijgrok, Gijs, Boyango, Ilanit, Weitzenberg, Merle M., Schröder, Sybrin P., Sarris, Alexi J. C., Meeuwenoord, Nico J., Bule, Pedro, Kayal, Yasmine, Ilan, Neta, Codée, Jeroen D. C., Vlodavsky, Israel, Overkleeft, Herman S., Davies, Gideon J., Wu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351465/
https://www.ncbi.nlm.nih.gov/pubmed/35881786
http://dx.doi.org/10.1073/pnas.2203167119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351465/
https://www.ncbi.nlm.nih.gov/pubmed/35881786
http://dx.doi.org/10.1073/pnas.2203167119

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