Cargando…

Molecular determinants of pH sensing in the proton-activated chloride channel

In response to acidic pH, the widely expressed proton-activated chloride (PAC) channel opens and conducts anions across cellular membranes. By doing so, PAC plays an important role in both cellular physiology (endosome acidification) and diseases associated with tissue acidosis (acid-induced cell de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Osei-Owusu, James, Kots, Ekaterina, Ruan, Zheng, Mihaljević, Ljubica, Chen, Kevin Hong, Tamhaney, Ami, Ye, Xinyu, Lü, Wei, Weinstein, Harel, Qiu, Zhaozhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351481/ https://www.ncbi.nlm.nih.gov/pubmed/35878032 http://dx.doi.org/10.1073/pnas.2200727119

Ejemplares similares

Inhibition of the proton-activated chloride channel PAC by PIP(2)
por: Mihaljević, Ljubica, et al.
Publicado: (2023)

Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC
por: Osei-Owusu, James, et al.
Publicado: (2022)

Structures and pH sensing mechanism of proton-activated chloride channel
por: Ruan, Zheng, et al.
Publicado: (2020)

Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
por: Osei-Owusu, James, et al.
Publicado: (2021)

PAC proton-activated chloride channel contributes to acid-induced cell death in primary rat cortical neurons
por: Osei-Owusu, James, et al.
Publicado: (2020)

Simulation of pH-Dependent Conformational Transitions in Membrane Proteins: The CLC-ec1 Cl(−)/H(+) Antiporter
por: Kots, Ekaterina, et al.
Publicado: (2021)

The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase
por: Khelashvili, George, et al.
Publicado: (2022)

Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV)
por: Choi, Annette, et al.
Publicado: (2023)

Voltage and pH sensing by the voltage-gated proton channel, H(V)1
por: DeCoursey, Thomas E.
Publicado: (2018)

RNA-Seq Analyses Reveal Roles of the HVCN1 Proton Channel in Cardiac pH Homeostasis
por: Wu, Xin, et al.
Publicado: (2022)

Structural dynamics determine voltage and pH gating in human voltage-gated proton channel
por: Han, Shuo, et al.
Publicado: (2022)

Computational Investigation of Mechanisms for pH Modulation of Human Chloride Channels
por: Elverson, Kathleen, et al.
Publicado: (2023)

Chloride channels regulate differentiation and barrier functions of the mammalian airway
por: He, Mu, et al.
Publicado: (2020)

Functional Modifications of Acid-Sensing Ion Channels by Ligand-Gated Chloride Channels
por: Chen, Xuanmao, et al.
Publicado: (2011)

Single chloride channels from Torpedo electroplax. Activation by protons
Publicado: (1983)

Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance
por: Leray, Xavier, et al.
Publicado: (2022)

Ion permeation controlled by hydrophobic residues and proton binding in the proton-activated chloride channel
por: Cai, Ruiqi, et al.
Publicado: (2021)

Gating choreography and mechanism of the human proton-activated chloride channel ASOR
por: Wang, Chongyuan, et al.
Publicado: (2022)

The proton channel OTOP1 is a sensor for the taste of ammonium chloride
por: Liang, Ziyu, et al.
Publicado: (2023)

A new polymodal gating model of the proton-activated chloride channel
por: Zhao, Piao, et al.
Publicado: (2023)

Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin
por: Miller, Alexandria N, et al.
Publicado: (2019)

Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands
por: Barth, Daniel, et al.
Publicado: (2019)

Dimer interaction in the Hv1 proton channel
por: Mony, Laetitia, et al.
Publicado: (2020)

Reduced H(+) channel activity disrupts pH homeostasis and calcification in coccolithophores at low ocean pH
por: Kottmeier, Dorothee M., et al.
Publicado: (2022)

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
por: Ullrich, Florian, et al.
Publicado: (2019)

State-dependent Inhibition of TRPM2 Channel by Acidic pH
por: Yang, Wei, et al.
Publicado: (2010)

Plant Trans-Golgi Network/Early Endosome pH regulation requires Cation Chloride Cotransporter (CCC1)
por: McKay, Daniel W, et al.
Publicado: (2022)

Cryo-EM structure of a proton-activated chloride channel TMEM206
por: Deng, Zengqin, et al.
Publicado: (2021)

A family of hyperpolarization-activated channels selective for protons
por: Wobig, Lea, et al.
Publicado: (2020)

Structure of the CLC-1 chloride channel from Homo sapiens
por: Park, Eunyong, et al.
Publicado: (2018)

MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1
por: Kino, Yoshihiro, et al.
Publicado: (2009)

Structure of the human volume regulated anion channel
por: Kefauver, Jennifer M, et al.
Publicado: (2018)

Muscle Chloride Channel Dysfunction in Two Mouse Models of Myotonic Dystrophy
por: Lueck, John D., et al.
Publicado: (2007)

Intriguing Chloride: Involvement of Chloride Ions in Proton Transfers
por: Pilepić, Viktor, et al.
Publicado: (2022)

Low pH Attenuates Apoptosis by Suppressing the Volume-Sensitive Outwardly Rectifying (VSOR) Chloride Current in Chondrocytes
por: Kittl, Michael, et al.
Publicado: (2022)

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A
por: Paulino, Cristina, et al.
Publicado: (2017)

Chloride Channels and Transporters: Roles beyond Classical Cellular Homeostatic pH or Ion Balance in Cancers
por: Kim, Hyeong Jae, et al.
Publicado: (2022)

LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions
por: Serra, Selma A., et al.
Publicado: (2021)

Proton-Binding Sites of Acid-Sensing Ion Channel 1
por: Ishikita, Hiroshi
Publicado: (2011)

Molecular mechanism of voltage sensing in voltage-gated proton channels
por: Gonzalez, Carlos, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2fmi99v9l6o75d9ink9ksj589u