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Agonist concentration–dependent changes in FPR1 conformation lead to biased signaling for selective activation of phagocyte functions
The bacteria-derived formyl peptide fMet-Leu-Phe (fMLF) is a potent chemoattractant of phagocytes that induces chemotaxis at subnanomolar concentrations. At higher concentrations, fMLF inhibits chemotaxis while stimulating degranulation and superoxide production, allowing phagocytes to kill invading...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351494/ https://www.ncbi.nlm.nih.gov/pubmed/35878025 http://dx.doi.org/10.1073/pnas.2201249119 |