Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes

Camelid single-domain antibodies, also known as nanobodies, can be readily isolated from naïve libraries for specific targets but often bind too weakly to their targets to be immediately useful. Laboratory-based genetic engineering methods to enhance their affinity, termed maturation, can deliver us...

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Detalles Bibliográficos
Autores principales: Mikolajek, Halina, Weckener, Miriam, Brotzakis, Z. Faidon, Huo, Jiandong, Dalietou, Evmorfia V., Le Bas, Audrey, Sormanni, Pietro, Harrison, Peter J., Ward, Philip N., Truong, Steven, Moynie, Lucile, Clare, Daniel K., Dumoux, Maud, Dormon, Joshua, Norman, Chelsea, Hussain, Naveed, Vogirala, Vinod, Owens, Raymond J., Vendruscolo, Michele, Naismith, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351521/
https://www.ncbi.nlm.nih.gov/pubmed/35858383
http://dx.doi.org/10.1073/pnas.2205412119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351521/
https://www.ncbi.nlm.nih.gov/pubmed/35858383
http://dx.doi.org/10.1073/pnas.2205412119

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