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A missense mutation in Kcnc3 causes hippocampal learning deficits in mice

Although a wide variety of genetic tools has been developed to study learning and memory, the molecular basis of memory encoding remains incompletely understood. Here, we undertook an unbiased approach to identify novel genes critical for memory encoding. From a large-scale, in vivo mutagenesis scre...

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Detalles Bibliográficos
Autores principales: Xu, Pin, Shimomura, Kazuhiro, Lee, Changhoon, Gao, Xiaofei, Simpson, Eleanor H., Huang, Guocun, Joseph, Chryshanthi M., Kumar, Vivek, Ge, Woo-Ping, Pawlowski, Karen S., Frye, Mitchell D., Kourrich, Saïd, Kandel, Eric R., Takahashi, Joseph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351536/
https://www.ncbi.nlm.nih.gov/pubmed/35881790
http://dx.doi.org/10.1073/pnas.2204901119