Incorporating family history of disease improves polygenic risk scores in diverse populations

Polygenic risk scores (PRSs) derived from genotype data and family history (FH) of disease provide valuable information for predicting disease risk, but PRSs perform poorly when applied to diverse populations. Here, we explore methods for combining both types of information (PRS-FH) in UK Biobank da...

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Detalles Bibliográficos
Autores principales: Hujoel, Margaux L.A., Loh, Po-Ru, Neale, Benjamin M., Price, Alkes L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351615/
https://www.ncbi.nlm.nih.gov/pubmed/35935918
http://dx.doi.org/10.1016/j.xgen.2022.100152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351615/
https://www.ncbi.nlm.nih.gov/pubmed/35935918
http://dx.doi.org/10.1016/j.xgen.2022.100152

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