Cargando…

The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling

Upon antigen binding, the B cell receptor (BCR) undergoes clustering to form a signalosome that propagates downstream signaling required for normal B cell development and physiology. BCR clustering is dependent on remodeling of the cortical actin network, but the mechanisms that regulate actin remod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Droubi, Alaa, Wallis, Connor, Anderson, Karen E., Rahman, Saifur, de Sa, Aloka, Rahman, Taufiq, Stephens, Len R., Hawkins, Philip T., Lowe, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351708/ https://www.ncbi.nlm.nih.gov/pubmed/35878408 http://dx.doi.org/10.1083/jcb.202112018

Ejemplares similares

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family
por: Mills, Stephen J., et al.
Publicado: (2016)

The inositol 5-phosphatase INPP5K participates in the fine control of ER organization
por: Dong, Rui, et al.
Publicado: (2018)

Duplicated zebrafish (Danio rerio) inositol phosphatases inpp5ka and inpp5kb diverged in expression pattern and function
por: Shukla, Dhyanam, et al.
Publicado: (2023)

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe
por: Luo, Na, et al.
Publicado: (2013)

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway
por: Nakatsu, Fubito, et al.
Publicado: (2015)

Species-specific difference in expression and splice-site choice in Inpp5b, an inositol polyphosphate 5-phosphatase paralogous to the enzyme deficient in Lowe Syndrome
por: Bothwell, Susan P., et al.
Publicado: (2010)

Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity
por: Kim, Hong Sug, et al.
Publicado: (2014)

Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase
por: Coon, Brian G., et al.
Publicado: (2009)

miR-181a-5p Promotes Proliferation and Invasion and Inhibits Apoptosis of Cervical Cancer Cells via Regulating Inositol Polyphosphate-5-Phosphatase A (INPP5A)
por: Yang, Meng, et al.
Publicado: (2018)

Epigenetic Inactivation of Inositol polyphosphate 4-phosphatase B (INPP4B), a Regulator of PI3K/AKT Signaling Pathway in EBV-Associated Nasopharyngeal Carcinoma
por: Yuen, Jessie Wai-Fong, et al.
Publicado: (2014)

Down-Regulation of Inpp5e Associated With Abnormal Ciliogenesis During Embryonic Neurodevelopment Under Inositol Deficiency
por: Yue, Huixuan, et al.
Publicado: (2021)

Endosome and INPP4B
por: Chew, Chen Li, et al.
Publicado: (2015)

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis
por: Xu, Qingwen, et al.
Publicado: (2016)

Decreased INPP5B expression predicts poor prognosis in lung adenocarcinoma
por: Deng, Jun, et al.
Publicado: (2022)

X-inactivation analysis of embryonic lethality in Ocrl(wt/−);Inpp5b(−/−) mice
por: Bernard, David J., et al.
Publicado: (2010)

Mutations in the inositol polyphosphate-5-phosphatase E gene link phosphatidyl inositol signaling to the ciliopathies
por: Bielas, Stephanie L., et al.
Publicado: (2009)

Expansion and Functional Divergence of Inositol Polyphosphate 5-Phosphatases in Angiosperms
por: Zhang, Zaibao, et al.
Publicado: (2019)

Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis
por: Sharif, Ali S., et al.
Publicado: (2021)

Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment
por: Wiessner, Manuela, et al.
Publicado: (2017)

The Inositol Polyphosphate 5-Phosphatase Ship Is a Crucial Negative Regulator of B Cell Antigen Receptor Signaling
por: Liu, Qiurong, et al.
Publicado: (1998)

Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca(2+) entry pathway
por: Rahman, Saifur, et al.
Publicado: (2017)

Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling
por: Bohdanowicz, Michal, et al.
Publicado: (2012)

Identification of Inhibitors of Inositol 5-Phosphatases through Multiple Screening Strategies
por: Pirruccello, Michelle, et al.
Publicado: (2014)

Stimulation of Inositol 1,4,5-Trisphosphate (IP(3)) Receptor Subtypes by Analogues of IP(3)
por: Saleem, Huma, et al.
Publicado: (2013)

INPP5E and Coordination of Signaling Networks in Cilia
por: Zhang, Renshuai, et al.
Publicado: (2022)

Activation of Akt by the Bacterial Inositol Phosphatase, SopB, is Wortmannin Insensitive
por: Cooper, Kendal G., et al.
Publicado: (2011)

Regulation of Inositol 1,4,5-Trisphosphate Receptors by cAMP Independent of cAMP-dependent Protein Kinase
por: Tovey, Stephen C., et al.
Publicado: (2010)

Differential Regulation of B Cell Development, Activation, and Death by the Src Homology 2 Domain–Containing 5′ Inositol Phosphatase (Ship)
por: Brauweiler, Anne, et al.
Publicado: (2000)

INPP5D regulates inflammasome activation in human microglia
por: Chou, Vicky, et al.
Publicado: (2023)

INPP4B suppresses prostate cancer cell invasion
por: Hodgson, Myles C, et al.
Publicado: (2014)

INPP4B is an oncogenic regulator in human colon cancer
por: Guo, S T, et al.
Publicado: (2016)

Tumor Suppressor Role of INPP4B in Chemoresistant Retinoblastoma
por: Miroschnikov, Natalia, et al.
Publicado: (2023)

Exploration of inositol 1,4,5-trisphosphate (IP(3)) regulated dynamics of N-terminal domain of IP(3) receptor reveals early phase molecular events during receptor activation
por: Chandran, Aneesh, et al.
Publicado: (2019)

Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity
por: Tran, Dang Minh, et al.
Publicado: (2023)

The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics
por: Nakatsu, Fubito, et al.
Publicado: (2010)

Mechanisms controlling membrane recruitment and activation of the autoinhibited SHIP1 inositol 5-phosphatase
por: Waddell, Grace L., et al.
Publicado: (2023)

ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane
por: Fujisawa, Sayaka, et al.
Publicado: (2021)

INPP5E Preserves Genomic Stability through Regulation of Mitosis
por: Sierra Potchanant, Elizabeth A., et al.
Publicado: (2017)

Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice
por: Ceyhan, Yasemin, et al.
Publicado: (2020)

Upregulation of MicroRNA-935 Promotes the Malignant Behaviors of Pancreatic Carcinoma PANC-1 Cells via Targeting Inositol Polyphosphate 4-Phosphatase Type I Gene (INPP4A)
por: Wang, Cuiyue, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_vjhalqqborct84g8gddmoggtn4