Mutant p53-microRNA-200c-ZEB2-Axis-Induced CPT1C Elevation Contributes to Metabolic Reprogramming and Tumor Progression in Basal-Like Breast Cancers

TP53 is mutated in more than 80% of basal-like breast cancers (BLBCs). BLBCs with TP53 mutation are usually high-grade and have worse responses to chemotherapy, leading to poor clinical outcomes. Wild-type p53 (WTp53) is well-accepted to promote fatty acid oxidation (FAO); however, in this study, we...

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Detalles Bibliográficos
Autores principales: Wang, Chen-Yun, Wang, Cing-Hong, Mai, Ru-Tsun, Chen, Ting-Wen, Li, Chia-Wei, Chao, Chi-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351713/
https://www.ncbi.nlm.nih.gov/pubmed/35936710
http://dx.doi.org/10.3389/fonc.2022.940402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351713/
https://www.ncbi.nlm.nih.gov/pubmed/35936710
http://dx.doi.org/10.3389/fonc.2022.940402

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