Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction

[Image: see text] PROTACs represent a promising modality that has gained significant attention for the treatment of cancer, Alzheimer’s disease, and so forth. Due to limited structural information of the POI-PROTAC-E3 ligase ternary complex, the discovery of active PROTACs relies on the screening of...

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Detalles Bibliográficos
Autores principales: Yan, Wei, Pan, Bo-Syong, Shao, Jingwei, Lin, Hui-kuan, Li, Hong-yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352171/
https://www.ncbi.nlm.nih.gov/pubmed/35936457
http://dx.doi.org/10.1021/acsomega.2c00245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352171/
https://www.ncbi.nlm.nih.gov/pubmed/35936457
http://dx.doi.org/10.1021/acsomega.2c00245

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