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Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction
[Image: see text] PROTACs represent a promising modality that has gained significant attention for the treatment of cancer, Alzheimer’s disease, and so forth. Due to limited structural information of the POI-PROTAC-E3 ligase ternary complex, the discovery of active PROTACs relies on the screening of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352171/ https://www.ncbi.nlm.nih.gov/pubmed/35936457 http://dx.doi.org/10.1021/acsomega.2c00245 |