Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation

Key protein adapters couple translation to mRNA decay on specific classes of problematic mRNAs in eukaryotes. Slow decoding on non-optimal codons leads to codon-optimality-mediated decay (COMD) and prolonged arrest at stall sites leads to no-go decay (NGD). The identities of the decay factors underl...

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Detalles Bibliográficos
Autores principales: Veltri, Anthony J, D'Orazio, Karole N, Lessen, Laura N, Loll-Krippleber, Raphael, Brown, Grant W, Green, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352352/
https://www.ncbi.nlm.nih.gov/pubmed/35894211
http://dx.doi.org/10.7554/eLife.76038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352352/
https://www.ncbi.nlm.nih.gov/pubmed/35894211
http://dx.doi.org/10.7554/eLife.76038

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