Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

Increased intracellular iron spurs mitochondrial biogenesis and respiration to satisfy high-energy demand during osteoclast differentiation and bone-resorbing activities. Transferrin receptor 1 (Tfr1) mediates cellular iron uptake through endocytosis of iron-loaded transferrin, and its expression in...

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Detalles Bibliográficos
Autores principales: Das, Bhaba K, Wang, Lei, Fujiwara, Toshifumi, Zhou, Jian, Aykin-Burns, Nukhet, Krager, Kimberly J, Lan, Renny, Mackintosh, Samuel G, Edmondson, Ricky, Jennings, Michael L, Wang, Xiaofang, Feng, Jian Q, Barrientos, Tomasa, Gogoi, Jyoti, Kannan, Aarthi, Gao, Ling, Xing, Weirong, Mohan, Subburaman, Zhao, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352353/
https://www.ncbi.nlm.nih.gov/pubmed/35758636
http://dx.doi.org/10.7554/eLife.73539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352353/
https://www.ncbi.nlm.nih.gov/pubmed/35758636
http://dx.doi.org/10.7554/eLife.73539

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