Reduced d-serine levels drive enhanced non-ionotropic NMDA receptor signaling and destabilization of dendritic spines in a mouse model for studying schizophrenia

Schizophrenia is a psychiatric disorder that affects over 20 million people globally. Notably, schizophrenia is associated with decreased density of dendritic spines and decreased levels of d-serine, a co-agonist required for opening of the N-methyl-d-aspartate receptor (NMDAR). We hypothesized that...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Deborah K., Petshow, Samuel, Anisimova, Margarita, Barragan, Eden V., Gray, John A., Stein, Ivar S., Zito, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352378/
https://www.ncbi.nlm.nih.gov/pubmed/35605760
http://dx.doi.org/10.1016/j.nbd.2022.105772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352378/
https://www.ncbi.nlm.nih.gov/pubmed/35605760
http://dx.doi.org/10.1016/j.nbd.2022.105772

Ejemplares similares