Cargando…

Intratumoral IL-28B Gene Delivery Elicits Antitumor Effects by Remodeling of the Tumor Microenvironment in H22-Bearing Mice

IL-28B, belonging to type III interferons (IFN-λs), exhibits a potent antitumor activity with reduced regulated T cells (Tregs) population, yet the effect of IL-28B on the tumor microenvironment (TME) and if IL-28B can downregulate Tregs directly in vitro are still unknown. In this study, we investi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zhi, Wang, Jianghua, Chen, Chong, He, Qi, Xu, Xiaoying, Da, Zejiao, Wang, Bo, Wang, Meng, Gao, Xiaotong, Zhang, Guochao, Gao, Qi, Si, Xiaoli, Luo, Yanping, Ma, Xingming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352479/ https://www.ncbi.nlm.nih.gov/pubmed/35935577 http://dx.doi.org/10.1155/2022/1345971

Ejemplares similares

In vivo effect of magnetic microspheres loaded with E2-a in the treatment of alveolar echinococcosis
por: Li, Zhi, et al.
Publicado: (2020)

The improved antitumor efficacy of continuous intratumoral chemotherapy with cisplatin-loaded implants for the treatment of sarcoma 180 tumor-bearing mice
por: Gao, Li, et al.
Publicado: (2019)

Synergism therapeutic and immunoregulatory effects of Albendazole + rAd-mIL-28B against Echinococcosis in experiment-infected mice with protoscoleces
por: Zhang, Yan, et al.
Publicado: (2021)

Intratumor microbiome features reveal antitumor potentials of intrahepatic cholangiocarcinoma
por: Chai, Xiaoqiang, et al.
Publicado: (2022)

Intratumoral delivery of a novel oncolytic adenovirus encoding human antibody against PD-1 elicits enhanced antitumor efficacy
por: Zhou, Ping, et al.
Publicado: (2022)

Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation
por: Chen, Lingjuan, et al.
Publicado: (2021)

CXCR6 is required for antitumor efficacy of intratumoral CD8(+) T cell
por: Wang, Binglin, et al.
Publicado: (2021)

Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin– chitosan nanoparticles loading paclitaxel– cholesterol complex
por: Chu, Xiao-Yang, et al.
Publicado: (2019)

A fully synthetic self-adjuvanting globo H-Based vaccine elicited strong T cell-mediated antitumor immunity
por: Zhou, Zhifang, et al.
Publicado: (2015)

Intratumor Heterogeneity and Antitumor Immunity Shape One Another Bidirectionally
por: Wolf, Yochai, et al.
Publicado: (2022)

Antitumor and immunomodulatory activities of total flavonoids extract from persimmon leaves in H(22) liver tumor-bearing mice
por: Chen, Li, et al.
Publicado: (2018)

Antitumor Efficacy and Mechanism in Hepatoma H22-Bearing Mice of Brucea javanica Oil
por: Shi, Wen-Rong, et al.
Publicado: (2015)

Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
por: Bahmani, Baharak, et al.
Publicado: (2021)

Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8(+) exhausted-like T cells
por: Li, Siqi, et al.
Publicado: (2023)

Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
por: Zuo, Bingfeng, et al.
Publicado: (2020)

Antitumor and immunomodulatory effects of low-dose 5-FU on hepatoma 22 tumor-bearing mice
por: CAO, ZHIYUN, et al.
Publicado: (2014)

Improved intratumoral penetration of IL12 immunocytokine enhances the antitumor efficacy
por: Jung, Keunok, et al.
Publicado: (2022)

Antitumor Effect of Zhihuang Fuzheng Soft Capsules on Tumor-Bearing Mice
por: Bao, Yanyan, et al.
Publicado: (2016)

Intratumoral injection of anlotinib hydrogel enhances antitumor effects and reduces toxicity in mouse model of lung cancer
por: Gao, Qin, et al.
Publicado: (2020)

Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice
por: Zhang, Cangang, et al.
Publicado: (2021)

Intratumoral injection of schwannoma with attenuated Salmonella typhimurium induces antitumor immunity and controls tumor growth
por: Ahmed, Sherif G., et al.
Publicado: (2022)

Live-attenuated Japanese encephalitis virus inhibits glioblastoma growth and elicits potent antitumor immunity
por: Qi, Zhongbing, et al.
Publicado: (2023)

Neutral polysaccharide from Panaxnotoginseng enhanced cyclophosphamide antitumor efficacy in hepatoma H22-bearing mice
por: Liu, Yan-Hong, et al.
Publicado: (2021)

Therapeutic and immunoregulatory effects of water-soluble alkaloids E2-a from Sophora moorcroftiana seeds as a novel potential agent against echinococcosis in experimentally protoscolex-infected mice
por: Luo, Yanping, et al.
Publicado: (2018)

Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats
por: Wang, Chunhua, et al.
Publicado: (2018)

Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells
por: Zhao, Songbo, et al.
Publicado: (2021)

Flubendazole Elicits Antitumor Effects by Inhibiting STAT3 and Activating Autophagy in Non-small Cell Lung Cancer
por: Xie, Xiaona, et al.
Publicado: (2021)

Antitumor Therapy Targeting the Tumor Microenvironment
por: Gao, Yuewen, et al.
Publicado: (2023)

Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer
por: Zhao, Zhucheng, et al.
Publicado: (2022)

Inhibition of colorectal cancer liver metastasis in BALB/c mice following intratumoral injection of oncolytic herpes simplex virus type 2 for the induction of specific antitumor immunity
por: Zhang, Wen, et al.
Publicado: (2019)

Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses
por: Jiang, Xiaodong, et al.
Publicado: (2019)

Antitumor Effects of Ethanol Extracts from Hyptis Rhomboidea in H(22) Tumor-bearing Mice
por: Cui, Hong-Xin, et al.
Publicado: (2017)

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection
por: vom Berg, Johannes, et al.
Publicado: (2013)

The protective effect and antitumor activity of Aconiti Lateralis Radix Praeparata (Fuzi) polysaccharide on cyclophosphamide-induced immunosuppression in H22 tumor-bearing mice
por: Hu, Qi, et al.
Publicado: (2023)

Strategies to Improve the Antitumor Effect of Immunotherapy for Hepatocellular Carcinoma
por: Xing, Rui, et al.
Publicado: (2021)

Multivalent Carbohydrate Nanocomposites for Tumor Microenvironment Remodeling to Enhance Antitumor Immunity
por: Hyun, Gyu Hwan, et al.
Publicado: (2023)

Chronopharmacology and Mechanism of Antitumor Effect of Erlotinib in Lewis Tumor-Bearing Mice
por: Wang, Peipei, et al.
Publicado: (2014)

Antitumor Effect of Pseudolaric Acid B Involving Regulation of Notch1/Akt Signaling Response in Human Hepatoma Cell In Vitro
por: Gao, Haijun, et al.
Publicado: (2022)

IDH Mutation Subgroup Status Associates with Intratumor Heterogeneity and the Tumor Microenvironment in Intrahepatic Cholangiocarcinoma
por: Xiang, Xiao, et al.
Publicado: (2021)

Use of magnetic resonance elastography to gauge meningioma intratumoral consistency and histotype
por: Shi, Yu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_psavm25pedt1oisuchvtfqeb7p