Population pharmacokinetic model to generate mechanistic insights in bile acid homeostasis and drug-induced cholestasis

Bile acids (BA) fulfill a wide range of physiological functions, but are also involved in pathologies, such as cholestasis. Cholestasis is characterized by an intrahepatic accumulation of BAs and subsequent spillage to the systemic circulation. The aim of the present study was to develop physiologic...

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Detalles Bibliográficos
Autores principales: de Bruijn, Véronique M. P., Rietjens, Ivonne M. C. M., Bouwmeester, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352636/
https://www.ncbi.nlm.nih.gov/pubmed/35876888
http://dx.doi.org/10.1007/s00204-022-03345-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352636/
https://www.ncbi.nlm.nih.gov/pubmed/35876888
http://dx.doi.org/10.1007/s00204-022-03345-8

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