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Population pharmacokinetic model to generate mechanistic insights in bile acid homeostasis and drug-induced cholestasis
Bile acids (BA) fulfill a wide range of physiological functions, but are also involved in pathologies, such as cholestasis. Cholestasis is characterized by an intrahepatic accumulation of BAs and subsequent spillage to the systemic circulation. The aim of the present study was to develop physiologic...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352636/ https://www.ncbi.nlm.nih.gov/pubmed/35876888 http://dx.doi.org/10.1007/s00204-022-03345-8 |