Generating experimentally unrelated target molecule-binding highly functionalized nucleic-acid polymers using machine learning

In vitro selection queries large combinatorial libraries for sequence-defined polymers with target binding and reaction catalysis activity. While the total sequence space of these libraries can extend beyond 10(22) sequences, practical considerations limit starting sequences to ≤~10(15) distinct mol...

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Detalles Bibliográficos
Autores principales: Chen, Jonathan C., Chen, Jonathan P., Shen, Max W., Wornow, Michael, Bae, Minwoo, Yeh, Wei-Hsi, Hsu, Alvin, Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352670/
https://www.ncbi.nlm.nih.gov/pubmed/35927274
http://dx.doi.org/10.1038/s41467-022-31955-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352670/
https://www.ncbi.nlm.nih.gov/pubmed/35927274
http://dx.doi.org/10.1038/s41467-022-31955-4

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