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Generating experimentally unrelated target molecule-binding highly functionalized nucleic-acid polymers using machine learning
In vitro selection queries large combinatorial libraries for sequence-defined polymers with target binding and reaction catalysis activity. While the total sequence space of these libraries can extend beyond 10(22) sequences, practical considerations limit starting sequences to ≤~10(15) distinct mol...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352670/ https://www.ncbi.nlm.nih.gov/pubmed/35927274 http://dx.doi.org/10.1038/s41467-022-31955-4 |