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Relationships between genome-wide R-loop distribution and classes of recurrent DNA breaks in neural stem/progenitor cells

Recent studies revealed classes of recurrent DNA double-strand breaks (DSBs) in neural stem/progenitor cells, including transcription-associated, promoter-proximal breaks and recurrent DSB clusters in late-replicating, long neural genes that may give rise to somatic brain mosaicism. The mechanistic...

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Detalles Bibliográficos
Autores principales:	Thongthip, Supawat, Carlson, Annika, Crossley, Magdalena P., Schwer, Bjoern
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352722/ https://www.ncbi.nlm.nih.gov/pubmed/35927309 http://dx.doi.org/10.1038/s41598-022-17452-0

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