The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors

Bites by elapid snakes (e.g. cobras) can result in life-threatening paralysis caused by venom neurotoxins blocking neuromuscular nicotinic acetylcholine receptors. Here, we determine the cryo-EM structure of the muscle-type Torpedo receptor in complex with ScNtx, a recombinant short-chain α-neurotox...

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Detalles Bibliográficos
Autores principales: Nys, Mieke, Zarkadas, Eleftherios, Brams, Marijke, Mehregan, Aujan, Kambara, Kumiko, Kool, Jeroen, Casewell, Nicholas R., Bertrand, Daniel, Baenziger, John E., Nury, Hugues, Ulens, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352773/
https://www.ncbi.nlm.nih.gov/pubmed/35927270
http://dx.doi.org/10.1038/s41467-022-32174-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352773/
https://www.ncbi.nlm.nih.gov/pubmed/35927270
http://dx.doi.org/10.1038/s41467-022-32174-7

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