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Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles

Human protein disulfide isomerase (PDI) is an essential redox-regulated enzyme required for oxidative protein folding. It comprises four thioredoxin domains, two catalytically active (a, a’) and two inactive (b, b’), organized to form a flexible abb’a’ U-shape. Snapshots of unbound oxidized and redu...

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Detalles Bibliográficos
Autores principales: Chinnaraj, Mathivanan, Flaumenhaft, Robert, Pozzi, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352907/
https://www.ncbi.nlm.nih.gov/pubmed/35780832
http://dx.doi.org/10.1016/j.jbc.2022.102217