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Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles
Human protein disulfide isomerase (PDI) is an essential redox-regulated enzyme required for oxidative protein folding. It comprises four thioredoxin domains, two catalytically active (a, a’) and two inactive (b, b’), organized to form a flexible abb’a’ U-shape. Snapshots of unbound oxidized and redu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352907/ https://www.ncbi.nlm.nih.gov/pubmed/35780832 http://dx.doi.org/10.1016/j.jbc.2022.102217 |