Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition

The recent development of mutant-selective inhibitors for the oncogenic KRAS(G12C) allele has generated considerable excitement. These inhibitors covalently engage the mutant C12 thiol located within the phosphoryl binding loop of RAS, locking the KRAS(G12C) protein in an inactive state. While clini...

Descripción completa

Detalles Bibliográficos
Autores principales: Huynh, Minh V., Parsonage, Derek, Forshaw, Tom E., Chirasani, Venkat R., Hobbs, G. Aaron, Wu, Hanzhi, Lee, Jingyun, Furdui, Cristina M., Poole, Leslie B., Campbell, Sharon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352912/
https://www.ncbi.nlm.nih.gov/pubmed/35753348
http://dx.doi.org/10.1016/j.jbc.2022.102186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352912/
https://www.ncbi.nlm.nih.gov/pubmed/35753348
http://dx.doi.org/10.1016/j.jbc.2022.102186

Ejemplares similares