The conformational change of the protease inhibitor α(2)-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel

The protease inhibitor α(2)-macroglobulin (A2M) is a member of the ancient α(2)-macroglobulin superfamily (A2MF), which also includes structurally related proteins, such as complement factor C3. A2M and other A2MF proteins undergo an extensive conformational change upon cleavage of their bait region...

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Detalles Bibliográficos
Autores principales: Harwood, Seandean Lykke, Diep, Khang, Nielsen, Nadia Sukusu, Jensen, Kathrine Tejlgård, Enghild, Jan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352918/
https://www.ncbi.nlm.nih.gov/pubmed/35787371
http://dx.doi.org/10.1016/j.jbc.2022.102230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352918/
https://www.ncbi.nlm.nih.gov/pubmed/35787371
http://dx.doi.org/10.1016/j.jbc.2022.102230

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