Cargando…
The conformational change of the protease inhibitor α(2)-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel
The protease inhibitor α(2)-macroglobulin (A2M) is a member of the ancient α(2)-macroglobulin superfamily (A2MF), which also includes structurally related proteins, such as complement factor C3. A2M and other A2MF proteins undergo an extensive conformational change upon cleavage of their bait region...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352918/ https://www.ncbi.nlm.nih.gov/pubmed/35787371 http://dx.doi.org/10.1016/j.jbc.2022.102230 |