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Modulation of blood pressure regulatory genes in the Agtrap‐Plod1 locus associated with a deletion in Clcn6

The AGTRAP‐PLOD1 locus is a conserved gene cluster containing several blood pressure regulatory genes, including CLCN6, MTHFR, NPPA, and NPPB. Previous work revealed that knockout of Clcn6 on the Dahl Salt‐Sensitive (SS) rat background (SS‐Clcn6) resulted in lower diastolic blood pressure compared t...

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Detalles Bibliográficos
Autores principales: Klemens, Christine A., Dissanayake, Lashodya V., Levchenko, Vladislav, Zietara, Adrian, Palygin, Oleg, Staruschenko, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353118/
https://www.ncbi.nlm.nih.gov/pubmed/35927940
http://dx.doi.org/10.14814/phy2.15417