V2 hotspot optimized MVA vaccine expressing stabilized HIV-1 Clade C envelope Gp140 delays acquisition of heterologous Clade C Tier 2 challenges in Mamu-A*01 negative Rhesus Macaques

Stabilized HIV envelope (Env) trimeric protein immunogens have been shown to induce strong autologous neutralizing antibody response. However, there is limited data on the immunogenicity and efficacy of stabilized Env expressed by a viral vector-based immunogen. Here, we compared the immunogenicity...

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Detalles Bibliográficos
Autores principales: Styles, Tiffany M., Gangadhara, Sailaja, Reddy, Pradeep B. J., Sahoo, Anusmita, Shiferaw, Ayalensh, Welbourn, Sarah, Kozlowski, Pamela A., Derdeyn, Cynthia A., Velu, Vijayakumar, Amara, Rama Rao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353326/
https://www.ncbi.nlm.nih.gov/pubmed/35935987
http://dx.doi.org/10.3389/fimmu.2022.914969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353326/
https://www.ncbi.nlm.nih.gov/pubmed/35935987
http://dx.doi.org/10.3389/fimmu.2022.914969

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