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A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer

Cancer stem cells (CSCs) are reported to play essential roles in chemoresistance and metastasis. Pathways regulating CSC self‐renewal and proliferation, such as Hedgehog, Notch, Wnt/β‐catenin, TGF‐β, and Myc, may be potential therapeutic targets. Here, a functional screening from the focused library...

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Detalles Bibliográficos
Autores principales: Zhou, Jun‐Nian, Zhang, Biao, Wang, Hai‐Yang, Wang, Dong‐Xing, Zhang, Ming‐Ming, Zhang, Min, Wang, Xiao‐Kui, Fan, Shi‐Yong, Xu, Ying‐Chen, Zeng, Quan, Jia, Ya‐Li, Xi, Jia‐Fei, Nan, Xue, He, Li‐Juan, Zhou, Xin‐Bo, Li, Song, Zhong, Wu, Yue, Wen, Pei, Xue‐Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353477/
https://www.ncbi.nlm.nih.gov/pubmed/35652264
http://dx.doi.org/10.1002/advs.202201166