Stiffening Matrix Induces Age‐Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions

Aging is a major risk factor in microvascular dysfunction and disease development, but the underlying mechanism remains largely unknown. As a result, age‐mediated changes in the mechanical properties of tissue collagen have gained interest as drivers of endothelial cell (EC) dysfunction. 3D culture...

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Detalles Bibliográficos
Autores principales: Schnellmann, Rahel, Ntekoumes, Dimitris, Choudhury, Mohammad Ikbal, Sun, Sean, Wei, Zhao, Gerecht, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353494/
https://www.ncbi.nlm.nih.gov/pubmed/35657074
http://dx.doi.org/10.1002/advs.202201483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353494/
https://www.ncbi.nlm.nih.gov/pubmed/35657074
http://dx.doi.org/10.1002/advs.202201483

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