Cargando…

Age-related increase of mitochondrial content in human memory CD4+ T cells contributes to ROS-mediated increased expression of proinflammatory cytokines

Cellular metabolism modulates effector functions in human CD4(+) T (Th) cells by providing energy and building blocks. Conversely, cellular metabolic responses are modulated by various influences, e.g., age. Thus, we hypothesized that metabolic reprogramming in human Th cells during aging modulates...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yuling, Ye, Yuanchun, Krauß, Pierre-Louis, Löwe, Pelle, Pfeiffenberger, Moritz, Damerau, Alexandra, Ehlers, Lisa, Buttgereit, Thomas, Hoff, Paula, Buttgereit, Frank, Gaber, Timo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353942/ https://www.ncbi.nlm.nih.gov/pubmed/35935995 http://dx.doi.org/10.3389/fimmu.2022.911050

Ejemplares similares

Production of IL-6 and Phagocytosis Are the Most Resilient Immune Functions in Metabolically Compromised Human Monocytes
por: Krauss, Pierre-Louis, et al.
Publicado: (2021)

Inhibition of Complex I of the Respiratory Chain, but Not Complex III, Attenuates Degranulation and Cytokine Secretion in Human Skin Mast Cells
por: Buttgereit, Thomas, et al.
Publicado: (2022)

Fracture Healing Research—Shift towards In Vitro Modeling?
por: Pfeiffenberger, Moritz, et al.
Publicado: (2021)

A Human Osteochondral Tissue Model Mimicking Cytokine-Induced Key Features of Arthritis In Vitro
por: Damerau, Alexandra, et al.
Publicado: (2020)

Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing
por: Gaber, Timo, et al.
Publicado: (2020)

Hypoxia and mesenchymal stromal cells as key drivers of initial fracture healing in an equine in vitro fracture hematoma model
por: Pfeiffenberger, Moritz, et al.
Publicado: (2019)

Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System
por: Strehl, Cindy, et al.
Publicado: (2019)

New insights into the fascinating world of glucocorticoids: the dexamethasone-miR-342-Rictor axis in regulatory T cells
por: Buttgereit, Frank, et al.
Publicado: (2021)

A new perspective is needed for positive selection of germinal center B cells with higher-affinity B cell receptors
por: Gaber, Timo, et al.
Publicado: (2022)

CTLA-4 Mediates Inhibitory Function of Mesenchymal Stem/Stromal Cells
por: Gaber, Timo, et al.
Publicado: (2018)

The Anti-Glucocorticoid Receptor Antibody Clone 5E4: Raising Awareness of Unspecific Antibody Binding
por: Ehlers, Lisa, et al.
Publicado: (2022)

Modification of the surface of superparamagnetic iron oxide nanoparticles to enable their safe application in humans
por: Strehl, Cindy, et al.
Publicado: (2016)

Human monocytes and macrophages differ in their mechanisms of adaptation to hypoxia
por: Fangradt, Monique, et al.
Publicado: (2012)

Proinflammatory Cytokines and Leptin Are Increased in Serum of Prepubertal Obese Children
por: Aygun, A. Denizmen, et al.
Publicado: (2005)

Metformin increases the expression of proinflammatory cytokines and inhibits supraspinatus fatty infiltration
por: Yoon, Jong Pil, et al.
Publicado: (2023)

JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration
por: Damerau, Alexandra, et al.
Publicado: (2020)

Increased Proinflammatory Cytokine Levels in Prolonged Arthralgia in Ross River Virus Infection
por: Tappe, Dennis, et al.
Publicado: (2017)

Plant-derived pectin nanocoatings to prevent inflammatory cellular response of osteoblasts following Porphyromonas gingivalis infection
por: Meresta, Anna, et al.
Publicado: (2017)

Serum proteomics in giant cell arteritis in response to a three-day pulse of glucocorticoid followed by tocilizumab monotherapy (the GUSTO trial)
por: Christ, Lisa, et al.
Publicado: (2023)

Effects of PVA coated nanoparticles on human immune cells
por: Strehl, Cindy, et al.
Publicado: (2015)

Proinflammatory Cytokines Increase Vascular Endothelial Growth Factor Expression in Alveolar Epithelial Cells
por: Maloney, James P., et al.
Publicado: (2015)

Atorvastatin increases the production of proinflammatory cytokines and decreases the survival of Escherichia coli-infected mice
por: Hussein, Hadi M., et al.
Publicado: (2019)

Lower Plasma Melatonin in the Intervertebral Disk Degeneration Patients Was Associated with Increased Proinflammatory Cytokines
por: Tian, Yixing, et al.
Publicado: (2021)

Intracerebral Proinflammatory Cytokine Increase in Surgically Evacuated Intracerebral Hemorrhage: A Microdialysis Study
por: Tobieson, Lovisa, et al.
Publicado: (2021)

Proinflammatory Cytokines in Peritonitis
por: Badiu, DC, et al.
Publicado: (2011)

Proinflammatory cytokine TNFα promotes HPV-associated oral carcinogenesis by increasing cancer stemness
por: Hong, Hannah S., et al.
Publicado: (2020)

Increased Hepatic Expression of SARS-CoV-2 Entry Points and Proinflammatory Cytokines in Cirrhosis
por: Limon-De La Rosa, Nathaly, et al.
Publicado: (2022)

Reducing the Toxicity of Long-Term Glucocorticoid Treatment in Large Vessel Vasculitis
por: Palmowski, Andriko, et al.
Publicado: (2020)

Increased Blood Levels of Growth Factors, Proinflammatory Cytokines, and Th17 Cytokines in Patients with Newly Diagnosed Type 1 Diabetes
por: Alnek, Kristi, et al.
Publicado: (2015)

Oxidized galectin-1 reduces lipopolysaccharide-induced increase of proinflammatory cytokine mRNA in cultured macrophages
por: Kogawa, Yukie, et al.
Publicado: (2011)

Heavy Ethanol Intoxication Increases Proinflammatory Cytokines and Aggravates Hemorrhagic Shock-Induced Organ Damage in Rats
por: Hu, Tsung-Ming, et al.
Publicado: (2013)

Kaposi’s Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes
por: Host, Kurtis M., et al.
Publicado: (2017)

A Pronounced Inflammatory Activity Characterizes the Early Fracture Healing Phase in Immunologically Restricted Patients
por: Hoff, Paula, et al.
Publicado: (2017)

Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling
por: Spies, Cornelia M, et al.
Publicado: (2014)

ROS Detoxification and Proinflammatory Cytokines Are Linked by p38 MAPK Signaling in a Model of Mature Astrocyte Activation
por: Nahirnyj, Adrian, et al.
Publicado: (2013)

Hypoxia Promotes Osteogenesis but Suppresses Adipogenesis of Human Mesenchymal Stromal Cells in a Hypoxia-Inducible Factor-1 Dependent Manner
por: Wagegg, Markus, et al.
Publicado: (2012)

Nanocoating with plant-derived pectins activates osteoblast response in vitro
por: Folkert, J, et al.
Publicado: (2016)

Modeling Rheumatoid Arthritis In Vitro: From Experimental Feasibility to Physiological Proximity
por: Damerau, Alexandra, et al.
Publicado: (2020)

Increased Hyperalgesia and Proinflammatory Cytokines in the Spinal Cord and Dorsal Root Ganglion After Surgery and/or Fentanyl Administration in Rats
por: Chang, Lu, et al.
Publicado: (2018)

Increased Serum Levels of Proinflammatory Cytokines Are Accompanied by Fatigue in Military T-6A Texan II Instructor Pilots
por: Damato, Elizabeth G., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ghkc9prakagd2cqf2s6po94sug