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Mitigating cold-start problems in drug-target affinity prediction with interaction knowledge transferring

Predicting the drug-target interaction is crucial for drug discovery as well as drug repurposing. Machine learning is commonly used in drug-target affinity (DTA) problem. However, the machine learning model faces the cold-start problem where the model performance drops when predicting the interactio...

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Detalles Bibliográficos
Autores principales: Nguyen, Tri Minh, Nguyen, Thin, Tran, Truyen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353967/
https://www.ncbi.nlm.nih.gov/pubmed/35788823
http://dx.doi.org/10.1093/bib/bbac269