Discovery of BRAF/HDAC Dual Inhibitors Suppressing Proliferation of Human Colorectal Cancer Cells

The combination of histone deacetylase inhibitor and BRAF inhibitor (BRAFi) has been shown to enhance the antineoplastic effect and reduce the progress of BRAFi resistance. In this study, a series of (thiazol-5-yl)pyrimidin-2-yl)amino)-N-hydroxyalkanamide derivatives were designed and synthesized as...

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Detalles Bibliográficos
Autores principales: Li, Yingjun, Huang, Yongjun, Cheng, Huimin, Xu, Fang, Qi, Ruxi, Dai, Botao, Yang, Yujian, Tu, Zhengchao, Peng, Lijie, Zhang, Zhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354042/
https://www.ncbi.nlm.nih.gov/pubmed/35936102
http://dx.doi.org/10.3389/fchem.2022.910353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354042/
https://www.ncbi.nlm.nih.gov/pubmed/35936102
http://dx.doi.org/10.3389/fchem.2022.910353

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