BSCI-18 ESTROGEN-DEPLETION DECREASES PROGRESSION OF ER¯ BRAIN METASTASES BY PROMOTING AN ANTI-TUMORAL LOCAL IMMUNE RESPONSE

We have shown that 17-β-Estradiol (E2) promotes brain metastasis (BM) of estrogen receptor negative (ER¯) BC cells by inducing neuroinflammatory ER+ astrocytes in the brain niche to secrete pro-metastatic factors critical for early brain colonization. E2-depletion prevented brain colonization of hum...

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Detalles Bibliográficos
Autores principales: Contreras-Zarate, Maria, Alvarez-Eraso, Karen, Littrell, Zachary, Tsuji, Nicole, Karam, Sana, Ormond, D Ryan, Kabos, Peter, Cittelly, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354195/
http://dx.doi.org/10.1093/noajnl/vdac078.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354195/
http://dx.doi.org/10.1093/noajnl/vdac078.016

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