Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice

p21-Activated kinase 4 (PAK4), one of the serine/threonine kinases activated by Rho-family GTPases, has been widely studied as an oncogenic protein that is overexpressed in many types of cancers. In our recent study, PAK4 upregulation was observed in mice exhibiting hepatic ischaemia-reperfusion (I/...

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Detalles Bibliográficos
Autores principales: Mao, Yuancheng, Lee, Eun, Yang, Xiaohui, Bae, Eun Ju, Jeon, Raok, Park, Byung-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354638/
https://www.ncbi.nlm.nih.gov/pubmed/35920284
http://dx.doi.org/10.1080/14756366.2022.2106478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354638/
https://www.ncbi.nlm.nih.gov/pubmed/35920284
http://dx.doi.org/10.1080/14756366.2022.2106478

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