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Enabling Role of Ligand-Driven Conformational Changes in Enzyme Evolution
[Image: see text] Many enzymes that show a large specificity in binding the enzymatic transition state with a higher affinity than the substrate utilize substrate binding energy to drive protein conformational changes to form caged substrate complexes. These protein cages provide strong stabilizatio...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354746/ https://www.ncbi.nlm.nih.gov/pubmed/35829700 http://dx.doi.org/10.1021/acs.biochem.2c00178 |