Cargando…

Inhibition of Rac1 in ventral hippocampal excitatory neurons improves social recognition memory and synaptic plasticity

Rac1 is critically involved in the regulation of the actin cytoskeleton, neuronal structure, synaptic plasticity, and memory. Rac1 overactivation is reported in human patients and animal models of Alzheimer’s disease (AD) and contributes to their spatial memory deficits, but whether Rac1 dysregulati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Haiwang, Ben Zablah, Youssif, Zhang, Haorui, Liu, An, Gugustea, Radu, Lee, Dongju, Luo, Xiao, Meng, Yanghong, Li, Song, Zhou, Changxi, Xin, Tao, Jia, Zhengping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354987/ https://www.ncbi.nlm.nih.gov/pubmed/35936771 http://dx.doi.org/10.3389/fnagi.2022.914491

Ejemplares similares

Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice
por: Zhang, Haiwang, et al.
Publicado: (2021)

LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases
por: Ben Zablah, Youssif, et al.
Publicado: (2021)

Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders
por: Zhang, Haorui, et al.
Publicado: (2021)

The Role of ADF/Cofilin in Synaptic Physiology and Alzheimer’s Disease
por: Ben Zablah, Youssif, et al.
Publicado: (2020)

Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain
por: Bonansco, Christian, et al.
Publicado: (2016)

Endomorphin-2 Decreases Excitatory Synaptic Transmission in the Spinal Ventral Horn of the Rat
por: Wu, Zhen-Yu, et al.
Publicado: (2017)

Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons
por: Honoré, Ève, et al.
Publicado: (2022)

Global trends and prospects about synaptic plasticity in Alzheimer’s disease: a bibliometric analysis
por: Zhang, Yingying, et al.
Publicado: (2023)

Neddylation regulates excitatory synaptic transmission and plasticity
por: Brockmann, Marisa M., et al.
Publicado: (2019)

Enhanced ventral hippocampal synaptic transmission and impaired synaptic plasticity in a rodent model of alcohol addiction vulnerability
por: Almonte, Antoine G., et al.
Publicado: (2017)

Signaling abnormality leading to excessive/aberrant synaptic plasticity in Alzheimer's disease
por: Kawabata, Shigeki
Publicado: (2022)

Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice
por: Nan, Xinyu, et al.
Publicado: (2022)

Excitatory to inhibitory connectivity shaped by synaptic and homeostatic plasticity
por: Clopath, Claudia, et al.
Publicado: (2015)

Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function
por: Kerr, Nathan R., et al.
Publicado: (2023)

Effect of exercise on cognitive function and synaptic plasticity in Alzheimer's disease models: A systematic review and meta-analysis
por: Guo, Linlin, et al.
Publicado: (2023)

Dopamine Modulates Homeostatic Excitatory Synaptic Plasticity of Immature Dentate Granule Cells in Entorhino-Hippocampal Slice Cultures
por: Strehl, Andreas, et al.
Publicado: (2018)

STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons
por: Yang, Juan, et al.
Publicado: (2020)

Iron accumulation in the ventral tegmental area in Parkinson's disease
por: Zhang, Dongling, et al.
Publicado: (2023)

Aberrant expression of FBXO22 is associated with propofol-induced synaptic plasticity and cognitive dysfunction in adult mice
por: Yang, Xiaoxuan, et al.
Publicado: (2022)

Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord
por: Carlsen, Eva Meier, et al.
Publicado: (2014)

Commentary: Prenatal Ethanol Exposure Persistently Alters Endocannabinoid Signaling and Endocannabinioid-Mediated Excitatory Synaptic Plasticity in Ventral Tegmental Area Dopamine Neurons
por: Ieong, Hada Fong-ha
Publicado: (2017)

Aβ/Amyloid Precursor Protein-Induced Hyperexcitability and Dysregulation of Homeostatic Synaptic Plasticity in Neuron Models of Alzheimer’s Disease
por: Martinsson, Isak, et al.
Publicado: (2022)

Hippocampal Feedforward Inhibition Focuses Excitatory Synaptic Signals into Distinct Dendritic Compartments
por: Willadt, Silvia, et al.
Publicado: (2013)

Synaptic Effects of Munc18-1 Alternative Splicing in Excitatory Hippocampal Neurons
por: Meijer, Marieke, et al.
Publicado: (2015)

Spatial regulation of coordinated excitatory and inhibitory synaptic plasticity at dendritic synapses
por: Ravasenga, Tiziana, et al.
Publicado: (2022)

Sex-dependent effects of chronic exercise on cognitive flexibility but not hippocampal Bdnf in aging mice
por: Short, Annabel K., et al.
Publicado: (2022)

Somatic Mutations Detected in Parkinson Disease Could Affect Genes With a Role in Synaptic and Neuronal Processes
por: Lobon, Irene, et al.
Publicado: (2022)

Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases
por: Huynh, Van N, et al.
Publicado: (2021)

Domestication of the Dog from the Wolf Was Promoted by Enhanced Excitatory Synaptic Plasticity: A Hypothesis
por: Li, Yan, et al.
Publicado: (2014)

Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 Pyramidal Neurons
por: Chen, Wen-Bing, et al.
Publicado: (2020)

TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons
por: Kougioumoutzakis, André, et al.
Publicado: (2020)

Unsupervised discrimination of patterns in spiking neural networks with excitatory and inhibitory synaptic plasticity
por: Srinivasa, Narayan, et al.
Publicado: (2014)

Less means more: The magnitude of synaptic plasticity along the hippocampal dorso‐ventral axis is inversely related to the expression levels of plasticity‐related neurotransmitter receptors
por: Dubovyk, Valentyna, et al.
Publicado: (2017)

Impaired Hippocampal Synaptic Plasticity and Enhanced Excitatory Transmission in a Novel Animal Model of Autism Spectrum Disorders with Telomerase Reverse Transcriptase Overexpression
por: Rhee, Jeehae, et al.
Publicado: (2018)

Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1
por: Cresto, Noemie, et al.
Publicado: (2022)

Gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects
por: Luo, Mingcui, et al.
Publicado: (2023)

Neuromodulation of hippocampal long-term synaptic plasticity
por: Palacios-Filardo, Jon, et al.
Publicado: (2019)

Inhibiting BDNF Signaling Upregulates Hippocampal H3K9me3 in a Manner Dependent On In Vitro Aging and Oxidative Stress
por: Ionescu-Tucker, Andra, et al.
Publicado: (2022)

Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin
por: McGregor, Gemma, et al.
Publicado: (2018)

Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses
por: Aldahabi, Mohammad, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bf08vje6dv52cidcpeuc83nb40